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About Orexin
Orexin, a neuropeptide, is involved in regulating neurobiological systems that respond to stressful stimuli, including changes in cognition, sleep-wake states, and appetite. Orexin neurons project to the hippocampus, which is involved in learning, memory, and spatial abilities. Orexin enhances hippocampal neurogenesis, which improves spatial learning and memory abilities, and mood. However, orexin deficiency can result in learning and memory deficits, and depression.
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2017.00357/full
https://pubmed.ncbi.nlm.nih.gov/10320718/#:~:text=Affiliation,of%20the%20ORX%20neuronal%20system.